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Other factors include: INFECTIONS AND MOLECULAR MIMICRY A persistent theory on the etiology of autoimmune diseases is that exposure to a particular peptide epitope in an environmental antigen might lead to immune reactivity to an amino acid sequence identical to that present in a human antigen such as the TSH-R, thyroperoxidase (TPO), or thyroglobulin (Tg)

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Metabolomics / Proteomics : High-throughput mass spectrometry technology can comprehensively analyze metabolites in cells, while metabolic flux analysis can track the dynamic changes of metabolites